José Francisco Antonio María de Alta Gracia de la Guerra y Carrillo was born at Santa Bárbara, Alta California, México, where he was baptized at the Presidio Chapel October 17, 1822 (BP Baptism 00623). He was the sixth child of Captain José Antonio Julián de la Guerra y Noriega, commander of the presidio, and María Antonia Juliana Carrillo y Lugo (SG Baptism 01314). He fathered two children (hijos naturales) with María del Rosario Lorenzana (May 13, 1816-ca. 1857). He married (1) María Petra Ascención Sepúlveda y Serrano at Santa Bárbara February 16, 1839. Following Ascensión's death in August 1844 he fathered a child with María Antonia Domínguez y Valenzuela. He married (2) his first wife's younger sister, María Concepción Sepúlveda y Serrano, at Santa Bárbara January 5, 1846. He became a U.S. citizen with the transfer of California's sovereignty in 1848 and remained a resident of Santa Bárbara his entire life.
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Children (all born Santa Barbara):
(with Rosario Lorenzana)
- Felipe Santiago (May 1, 1837-Sep. 20, 1923)
- Cleotilda Inez Soledad (May 9, 1839-May 31, 1918; married Andronico Encarnación Sepúlveda y Ávila)

(with Ascención Sepúlveda)
- José Francisco Guadalupe (Apr. 9, 1840, bp Apr 10 Presidio Chapel-May 18, 1918)
- María Antonia Adelaída "la Tuna" (Oct. 31, 1841-Dec. 12, 1922; married Jose Francisco Ulpiano Yndart y Arburu)

(with María Antonia Domínguez)
- María Antonia (Jun. 15, bap. 16, 1846 [BP Baptism 01711Y] - Nov. 13, 1916; m. Louis Adrian Davoust in 1865)

(with Concepción Sepúlveda)
- Juan José (May 23, 1847-Dec. 19, 1940)
- María "Anita" Concepción Ramona (Dec. 16, 1849-June 22, 1935, LA; married Francisco A. Thompson)
- Osbaldo (Jan. 11, 1854-Apr. 26, 1898)
- Herlinda (Aug. 5, 1857-Mar. 9, 1921; married Ygnacio Sepúlveda)
- José "el Peregrino" (Jun. 25, 1860-June 18, 1877)
- María Rosa Blanca (Oct. 23, 1861-Oct. 2, 1938, San Antonio, TX; married George William West)
- José Hercules (1863-Jan. 22, 1905, Mexico City, MX)
- Victoria Diana (Mar. 13, 1867-Dec. 23, 1955, LA; married Bertoldo Eustasio Rico y Sepúlveda)
- Pablo Eduardo Ramón (July 19, 1868-Nov. 22, 1882)
- Hannibal Absalom (Oct 16, 1869-Jan. 4, 1953; married Angela Behn)
- Victor Alfredo (Oct. 24, 1870-Before 1921)
- Joaquín Cipio Genardo (Feb. 27, 1872-Before 1921)