Marianna Ashby Irwin, 87, was the daughter of W. Wallace and Nellie Graybill Ashby of Ladoga, Indiana. She graduated from Indiana University where she was very involved with numerous academic clubs including Pi Beta Phi sorority and Phi Beta Kappa honorary society. She married Glenn W. Irwin, Jr., on December 26, 1943, while he was a senior in the IU School of Medicine. She is survived by her husband and their two daughters, Ann Warden and Beth Schiffli, their son William Irwin, seven grandchildren, and two great grandchildren. Mrs. Irwin was known for her energy and warmth. She hosted uncountable events when Dr. Irwin served as IUPUI's second chancellor and School of Medicine dean. She was very active in the community serving on the boards and as an officer of the Junior League of Indianapolis, Marion County Medical Society Auxiliary, Indiana State Medical Auxiliary, North Central High School PTA, Noble School, Social Health Association, and Marion County Child Guidance Clinic. Other board memberships included the YWCA, Indiana Repertory Theatre, Methodist Health Foundation, American Red Cross, Indiana State Symphony Society, Mayor's Advisory Council Cultural Affairs, Indianapolis Art League, Second Presbyterian Women's Association, Indiana Regional Blood Center, and Multiple Sclerosis Association. In the latter years of her life, Mrs. Irwin suffered from primary progressive aphasia, a rare neurological disease that affects the ability to remember and understand words. It is among the neurodegenerative disorders explored by researchers at our Indiana Alzheimer Disease Center and Stark Neurosciences Research Institute. Funeral services April 21, 2010 at Second Presbyterian Church, Indianapolis with calling at the church prior to the service.