Chickasaw Advisor Leader. Probably born in Chickasaw Old Fields (Alabama). As a young man he served with General Anthony Wayne against the Shawnee in the Old Northwest and received a silver medallion from President Washington for his service. During the War of 1812, he served under Andrew Jackson. It is known that he received two tracts of land under the Pontotoc Treaty of 1832. After his service, he took several trips to Philadelphia and Washington DC before retiring to raise livestock and hunt until white settlers encroached on his land. New treaties took away land and rights from the Chickasaw until 1837 when a final treaty forced them to remove to Indian Territory (present day Oklahoma) with the Choctaw. About 4000 Chickasaw moved west in the winter of 1837 to 1838.

According to Tishomingo's son Richard, Tishomingo died c. 1838 on Brushy Creek, Choctaw Nation, Indian Territory (Oklahoma) on the same day his wife named "U Kuth Le Ya" died. This was during the time both Chickasaw and Choctaw tribes resided together in Indian Territory. Both Tishomingo and his wife's burial was witnessed by two Chickasaw Warriors who served with Tishomingo in the War of 1812 and gave their testimony attesting to this fact to the Indian Agent Douglas H. Cooper on September 27, 1859 in accordance with the requirements of a Bounty Land Application of Tishomingo's son Richard.

Chief Tishomingo was reported to have had a Lithotomy or kidney stone operation March 25, 1821 in Columbus, Mississippi performed by Dr. Henderson and Dr. Barry. The article stated, "The patient is supposed to be in his 63d year." This would place his birth approximately in the year 1758 and death in 1838 at the approximate age of 80.

The town of Tishomingo, Oklahoma as well as the town of Tishomingo, Mississippi are named for him. Additionally, Tishomingo county and Tishomingo Creek in Mississippi are named for him.