Early American Frontiersman. He was born in North Carolina, the 7th child and 3rd son of famed American frontiersman and explorer Daniel Boone and Rebecca Bryan Boone. As a child, he accompanied his father on hunting trips and soon grew accustomed to traveling through the unknown wilderness. In 1797, at the request of his father, he traveled to the St. Charles district of present-day eastern Missouri and visited with the Spanish lieutenant governor, Zenon Trudeau, who gave him a land grant near present-day Matson, Missouri. Trudeau encouraged him to have his father move there also, with the promise of receiving land and two years later his parents arrived in the area with a group of settlers. He built a home and his parents would live there until their deaths. He made his living as a hunter and trapper and also conducted government land surveys in what are now St. Charles, Warren, Montgomery, and Lincoln counties in Missouri. Around 1805 he and his brother Nathan opened a salt-making operation at a "salt lick" near present-day Boonville. The road they constructed to get there became known as Boone's Lick Trail or Boone's Lick Road, and it enabled settlers to reach central Missouri. He was also an outfitter for the westward trails and owned a store in Westport, Missouri, which is now part of Kansas City. During the War of 1812, he served as a captain in the Missouri militia, working as a spy and patrolling the frontier. In 1826 he moved to present-day Jackson County, Missouri and soon afterward relocated to the Kansas Territory, near the present-day city of Lawrence. He later moved back to Jackson County, Missouri where he died of cholera at the age of 69.

One wall of his home in Kansas City remain in the archives of the Kansas City Museum and that there is a marker at his homeplace near the South-Broadway Presbyterian church